发明名称 NOVEL COMPOUNDS
摘要 The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
申请公布号 US2017121313(A1) 申请公布日期 2017.05.04
申请号 US201515314106 申请日期 2015.05.26
申请人 GlaxoSmithKline Intellectual Property Development Limited 发明人 DENG Jing;LEI Hui;MA Xin;REN Feng;CAI Wei;LIN Xichen
分类号 C07D403/14;C07D241/04;C07D403/12;C07D403/06;C07D401/06;C07D401/12;C07D401/14 主分类号 C07D403/14
代理机构 代理人
主权项 1. A compound of Formula I or a pharmaceutically acceptable salt thereofwherein: R1 is: methyl substituted with i) C4-C6 cycloalkyl optionally substituted with a) one or two F or b) OH; or ii) 5 or 6 membered heterocycloalkyl substituted with C(O)CH3;C2-C3 alkyl substituted with CF3 or —SO2CH3;6 membered heteroaryl containing 1 or 2 N atom, said heteroaryl is optionally substituted with one to two substituents selected from the group consisting of C1-C3 alkyl, halo, CN and methoxy; orphenyl substituted with CN, R2 is C1-C3 alkyl, R3 is halo or CN; R4 is H; R5 is C1-C3 alkyl; R6 is H or methyl, and R7 is selected from the group consisting of. 4 to 6 membered heterocycloalkyl containing 1 N atom, wherein said heterocycloalkyl is optionally substituted with methyl;NRaRb, wherein said Ra is H or methyl, and said Rb is selected from the group consisting of i) methyl substituted with C3-C4 cycloalkyl, ii) C4-C5 cycloalkyl optionally substituted with methyl, and iii) C3-C4 alkyl; andORc, wherein said Rc is i) C4-C5 cycloalkyl; or ii) methyl substituted with C3-C4 cycloalkyl
地址 Brentford, Middlesex GB