THERAPEUTIC NANOPARTICLES AND METHODS THEREOF

摘要

Described herein is a method of preparing a hybrid hydrogel paramagnetic nanoparticle. In certain embodiments, the hybrid hydrogel paramagnetic nanoparticle comprises a therapeutic agent. In certain embodiments, the nanoparticle contains alcohol. In certain embodiments, the nanoparticles incorporate fatty acids. Also described herein, is a method of preparing a hybrid hydrogel NO-releasing nanoparticle. In another embodiment, provided herein is a method of preparing a S-nitrosocaptopril hydrogel nanoparticle. Also described herein is a method of preparing a curcumin-based hydrogel nanoparticle. Further, described herein is a method for treating a bacterial infection in a burn wound using curcumin-based hydrogel nanoparticles. Also provided herein is a method of treating a fungal infection using photoactivated curcumin-based hydrogel nanoparticles. In certain embodiments, the fungal infection is caused by dermatophytic fungi.

主权项

1. A method of preparing a hybrid hydrogel paramagnetic nanoparticle comprising the steps of:
(a) hydrolyzing TMOS; (b) sonicating the hydrolyzed TMOS to form a TMOS solution; (c) mixing deionized water with gadolinium chloride hexahydrate, europium chloride hexahydrate, PEG, chitosan, and methanol to form a mixture; (d) vortexing the mixture; (e) mixing the TMOS solution, an amine-containing silane, and ammonium hydroxide with the mixture to form a hydrogel mixture; (f) vortexing the hydrogel mixture to form a hydrogel; (g) lyophilizing the resulting hydrogel to form a dry material; (h) ball-malling the dry material to form a powder; and (i) mixing the resulting powder with an amine-binding PEG.