IMIDAZOLE COMPOUND AND LIPOSOME CONTAINING SAME

摘要

Provided are a novel imidazole compound which has a high stability of the compound itself; and a novel imidazole compound which is useful as a membrane-constituting lipid of liposomes. Disclosed are a compound represented by the following General Formula (1), and a liposome containing the same compound.;;In the formula, Z is an imidazolyl group which may be substituted, L1 is an alkylene group having 1 to 4 carbon atoms which may be substituted, X is an oxygen atom or a nitrogen-containing substituent, n is an integer of 2 to 4, m is an integer of 1 to 20, L2 is a divalent linking group having 1 to 6 carbon atoms, Y is a nitrogen-containing group, R1 and R2 are a hydrogen group or an alkyl group having 1 to 6 carbon atoms, R3 is a hydrogen atom or a substituent, and R4 and R5 are an alkyl group having 1 to 40 carbon atoms.

主权项

1. A compound represented by the following General Formula (1): in Formula (1), Z is an imidazolyl group which may have a substituent, L1 is an alkylene group having 1 to 4 carbon atoms which may have a substituent, and X is an oxygen atom or a group represented by the following Formula (2), * is a position of bonding, n is an integer of 2 to 4, m is an integer of 1 to 20, L2 is a divalent linking group having 1 to 6 carbon atoms, and Y is a group represented by the following Formula (3), R1 and R2 are the same or different and are a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R3 is a hydrogen atom or a substituent, and R4 and R5 are the same or different and are an alkyl group having 1 to 40 carbon atoms.