摘要 |
PURPOSE:To obtain a remedy for diseases accompanying vitamin D3 metabolism disorder, having strongly modulating action on calcium, by adding a novel vitamin D3 derivative as an active ingredient. CONSTITUTION:A novel 1alpha-hydroxyvitamin D3 shown by the formula (R is H or OH; A is 1-6C alkyl) containing a substituent group at the 2beta position is pharmaceutically manufactured into the form of oral agent, injection, etc., to give the aimed substance. A dose is 0.01-10mug, preferably 0.1-5mug. Diseases accompanying vitamin D metabolism disorder, to be concrete, are chronic renal insufficiency, hypoparathyroidism, rickets., vitamin D3-resistant rickets, osteomalacia, osteoporosis, etc.
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