发明名称 |
N-substituted diphenylpiperidines and antiobesity use thereof |
摘要 |
Compounds of the formula <IMAGE> I wherein R1 is <IMAGE> the asterisk denotes the specific bonding orientation to the piperidine moiety; R2 is alkylene or -CO-(CH2)n- wherein n is 0 to 11; R3 and R4, independently, are hydrogen, halogen or lower alkoxy; and HET is pyridinyl, pyrimidinyl or imidazolyl, and salts thereof with pharmaceutically acceptable acids, are described. The compounds of formula I exhibit insulin lowering activity and are useful as antiobesity agents.
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申请公布号 |
US4632925(A) |
申请公布日期 |
1986.12.30 |
申请号 |
US19850785113 |
申请日期 |
1985.10.07 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
MULLIN, JR., JOHN G.;KIERSTEAD, RICHARD W.;TRISCARI, JOSEPH |
分类号 |
C07D401/06;A61K31/44;A61K31/4427;A61K31/445;A61K31/505;A61P3/06;A61P5/38;(IPC1-7):A61K31/505;C07D211/68;C07D239/02 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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