N-domain of carcinoembryonic antigen and compositions, methods and uses thereof

摘要

The present disclosure provides immunogenic compositions comprising the N-domain of carcinoembryonic antigen (CEA). These compositions are useful for inducing or enhancing an immune response, for inhibiting tumor cell growth and for treating cancer.

主权项

1. A method of inducing an immune response against human carcinoembryonic antigen (CEA) In an animal in need thereof comprising administering an immunogenic composition comprising a peptide consisting of an N-domain of human carcinoembryonic antigen (CEA) which generates CEA N-domain specific sera, to the animal in need thereof; wherein the human N-domain consists of the immunoglobulin variable-like N-terminal region of human CEA and a spacer sequence.