| 发明名称 | Synthetic platelets | ||
| 摘要 | A synthetic platelet includes a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides conjugated to the surface, the peptides including a plurality of von Willebrand factor-binding peptides (VBPs), collagen-binding peptides (CBPs) and an active platelet GPIIb-IIIa-binding peptides (GBPs). | ||
| 申请公布号 | US9636383(B2) | 申请公布日期 | 2017.05.02 |
| 申请号 | US201514826387 | 申请日期 | 2015.08.14 |
| 申请人 | Case Western Reserve University | 发明人 | Sen Gupta Anirban;Ravikumar Madhumitha |
| 分类号 | A61K38/00;A61K38/39;C07K14/745;A61K38/17;A61K47/48;A61K9/127;A61K9/48;B82Y5/00 | 主分类号 | A61K38/00 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A method of promoting aggregation of activated platelets on a site with exposed vWF and collagen, the method comprising: administering to the site with exposed vWF and collagen a synthetic platelet comprising a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides conjugated to the surface, the peptides including a plurality of von Willebrand factor-binding peptides (VBPs), collagen-binding peptides (CBPs) and an active platelet GPIIb-IIIa-binding peptides (GBPs), wherein the synthetic platelet adheres to a vascular surface, vascular disease site, and/or vascular injury site with exposed von Willebrand factor and collagen and promotes arrest and aggregation of active platelets onto sites of the synthetic platelet adhesion. | ||
| 地址 | Cleveland OH US | ||