Methods for radiation protection by administering IL-12

摘要

Aspects and embodiments of the instant disclosure provide therapeutic methods and compositions comprising interleukin 12 (IL-12) useful for treating radiation-induced damage in a subject. In particular, the instant disclosure provides methods and compositions for radiation protection and/or radiation toxicity mitigation for the treatment of acute radiation syndrome and radiation induced toxicity associated with the treatment of cutaneous T-cell lymphoma.

主权项

1. A method of protecting a human subject from damage to immune system, gastrointestinal system, mucosal immune system, or mucosal tissue, following exposure of the subject to radiation between 0.7 Gy and 50 Gy, the method comprising:
administering a pharmaceutical composition comprising substantially isolated rIL-12 to the subject in an amount of between 10 ng/kg to 200 ng/kg of rIL-12, whereby cellular damage to the immune system, gastrointestinal system, or mucosal tissue, due to radiation, is diminished and wherein the subject is receiving radiation for head and neck cancer.