Nanoparticle compositions of antibacterial compounds and other uses thereof

摘要

The present disclosure relates to the development of antibacterial compounds and their nanoparticle compositions. Methods of making the compounds and their nanoparticle compositions, their use as medicament for the treatment of bacterial infection and also for suppressing potentially harmful inflammation are disclosed.

主权项

1. A compound of Formula I: wherein,
‘m’ is an integer ranging from 0 to 1,‘L’ is an integer ranging from 1 to 100,R1, R2 and R3 are, independently at each occurrence, a hydrogen atom or methyl radical orC2-C40 aliphatic radical or C3-C40 aromatic radical or any combination thereof, andX⊖ is selected from a group consisting of chloride, bromide and iodide;
and wherein at least one of R1, R2, or R3 comprises a structural moiety selected from a group consisting of: wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and n is an integer ranging from 1 to 4, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and n is an integer ranging from 1 to 4, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and n is an integer ranging from 1 to 4, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and n is an integer ranging from 1 to 4, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and n is an integer ranging from 1 to 4, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and y is an integer ranging from 0 to 3, wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and y is an integer ranging from 0 to 3, and wherein, P is a C1-C24 aliphatic saturated radical or a C2-C24 aliphatic unsaturated radical, and y is an integer ranging from 0 to 3.