| 主权项 |
1. A compound of formula (I):wherein
each R1 is hydrogen, halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, hydroxy, —SO2NR6R7, —CN, —NR8SO2R9, —NR6R7, —CONR6R7, or —NR8COR9, wherein said (C1-C4) alkyl is optionally substituted by one or more groups selected from (C3-C7) cycloalkyl, hydroxyl, and —NR6R7 and wherein said (C1-C4) alkoxy is optionally substituted by one or more halogens or (C3-C7) cycloalkyl groups, wherein
R6 is hydrogen or (C1-C6) alkyl;R7 is hydrogen or (C1-C6) alkyl;R8 is hydrogen or (C1-C6) alkyl;R9 is hydrogen or (C1-C6) alkyl; n is an integer ranging from 1 to 3; each R2 is hydrogen, halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4)haloalkyl, hydroxy, —SO2NR10R11, —CN, or —NR12SO2R13, wherein said (C1-C4) alkyl and said (C1-C4) alkoxy are optionally substituted by one or more (C3-C7) cycloalkyl groups, wherein
R10 is hydrogen or (C1-C6) alkyl;R11 is hydrogen or (C1-C6) alkyl;R12 is hydrogen or (C1-C6) alkyl;R13 is hydrogen or (C1-C6) alkyl; m is an integer ranging from 1 to 3; R3 and R4 are the same or different and are independently: H; (C3-C7) cycloalkylcarbonyl; (C1-C6) alkyl optionally substituted by one or more substituents selected from the group consisting of (C1-C4) alkoxy, (C3-C7) cycloalkyl, and (C5-C7) cycloalkenyl; (C1-C6) haloalkyl; (C3-C7) cycloalkyl; (C5-C7) cycloalkenyl; (C2-C6) alkenyl; or (C2-C6) alkynyl; each R5, whenever present, is CN, NO2, CF3, or halogen; k is 0 or an integer ranging from 1 to 3; W1 is a divalent heteroarylene group; W2 is an aryl group, a heteroaryl group, or (C3-C7) cycloalkyl; L is a bond or a —(CH2)— group; L1 is: a bond, —(CH2)p—, [3]-(CH2)p—O-[4], [3]-(CH2)p—NR10—(CH2)-[4], [3]-(CH2)p—OC(O)-[4], [3]-(CH2)p—NR10C(O)-[4], [3]-(CH2)p—NR10S(O2)-[4], or [3]-(CH2)p—S(O2)—N(R10)-[4], wherein [3] and [4] represent, respectively the point of attachment of group L1 to the carbonyl group and to the ring W1 and wherein
R10 is as described above,p is an integer ranging from 1 to 4 andt is an integer ranging from 1 to 4; L2 is —(CH2)q— wherein q is an integer ranging from 1 to 4; L3 is a (C1-C4) alkylene; X is a group X1, X2, or X3: wherein [1] represents at each occurrence the point of attachment of the group X to L2, [2a] represents at each occurrence the point of attachment to L-W2 and [2b] represents at each occurrence the point of attachment to the carbonyl group —CO2A; and wherein
R14 is H, OH, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, or —CN, wherein said (C1-C4) alkyl is optionally substituted by one or more groups selected from (C3-C7) cycloalkyl and hydroxyl, or, in the alternative, when R14 is (C1-C4) alkyl, W2 is a phenyl ring, one of R1 is an alkyl in ortho position with respect to L, both R1 and R14 may be connected to form with W2 a condensed ring radical selected from at least 1H-cyclopropabenzene-1,1-diyl, indane-1,1-diyl (also named as 2,3-dihydro-1H-indene-1,1-diyl), indane-2,2-diyl (also named as 2,3-dihydro-1H-indene-2,2-diyl), 1,2,3,4-tetrahydronaphthalene-1,1-diyl, and 1,2,3,4-tetrahydronaphthalene-2,2-diyl;R15 is hydrogen, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C3-C7) heterocycloalkyl or benzyl; wherein said (C1-C6) alkyl is optionally substituted by hydroxyl or NR18R19; said R18 and R19 being independently hydrogen or (C1-C4) alkyl, or, taken together with the nitrogen atom to which they are attached, form a nitrogen containing, saturated heterocycloalkyl group, optionally containing an additional heteroatom selected from O, S and NH;and whereini is 1 or 2;i′ is 1 or 2;i″ is an integer ranging from 0 to 3; A is a group of formula (i) to (vi): wherein R16 is in each occurrence independently (C1-C4) alkyl optionally substituted by one or more (C1-C4) alkoxy groups; R17 is hydrogen, halogen or (C1-C4) alkyl; f=0, 1, 2 or 3; g=0, 1, 2 or 3; and the asterisk (*) represents the point of attachment to the group L3 in formula (I),an N-oxide on the pyridine ring, a deuterated derivative, or a pharmaceutically acceptable salt thereof. |
