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1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof:wherein: each of R1, R5, R9, and R10, independently, is H or C1-C6 alkyl; each of R2, R3, and R4, independently, is -Q1-T1, in which Q1 is a bond or C1-C3 alkyl linker optionally substituted with halo, cyano, hydroxyl or C1-C6 alkoxy, and T1 is H, halo, hydroxyl, COOH, cyano, or RS1, in which RS1 is C1-C3 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxyl, C(O)O—C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, 4 to 7-membered heterocycloalkyl, or 5 to 6-membered heteroaryl, and RS1 is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, oxo, COOH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, and 5 to 6-membered heteroaryl; R6 is H, halo, C1-C3 alkyl substituted with one or more -Q2-T2, C2-C6 alkenyl, C4-C6 cycloalkyl, C(O)H, ORa, —C(O)Ra, phenyl, 5 to 6-membered heteroaryl containing 1-3 heteroatoms selected from N, O, and S, or 4 to 7-membered heterocycloalkyl, in which Ra is C1-C6 alkyl or 4 to 7-membered heterocycloalkyl, and each of the phenyl, the 5 to 6-membered heteroaryl, and the 4 to 7-membered heterocycloalkyl is optionally substituted with one or more -Q2-T2, wherein Q2 is a bond or C1-C3 alkyl linker each optionally substituted with halo, cyano, hydroxyl or C1-C6 alkoxy, and T2 is H, halo, cyano, —ORc, —NRcRd, —(NRcRdRd)+A−, —C(O)Rc, —C(O)ORc,—C(O)NRcRd, —NRdC(O)Rc, —NRdC(O)ORc, —S(O)2Rc, —S(O)2NRcRd, or RS4, in which each of Rc Rd, and Rd′, independently is H or RS5, A− is a pharmaceutically acceptable anion, each of RS4 and RS5, independently, is C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, or 5 to 6-membered heteroaryl, or Rc and Rd, together with the N atom to which they are attached, form a 4 to 7-membered heterocycloalkyl ring having 0 or 1 additional heteroatoms to the N atom, and each of RS4, RS5, and the 4 to 7-membered heterocycloalkyl ring containing Rc and Rd, is optionally substituted with one or more -Q3-T3, wherein Q3 is a bond or C1-C3 alkyl linker each optionally substituted with halo, cyano, hydroxyl or C1-C6 alkoxy, and T3 is selected from the group consisting of H, halo, cyano, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, 5 to 6-membered heteroaryl, ORe, COORe, —S(O)2Re,—NReRf, and —C(O)NReRf, each of Re and Rf independently being H or C1-C6 alkyl; or -Q3-T3 is oxo; or -Q2-T2 is oxo; or any two neighboring -Q2-T2, together with the atoms to which they are attached form a 5- or 6-membered ring optionally containing 1-4 heteroatoms selected from N, O and S and optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, COOH, C(O)O—C1-C6 alkyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, and 5 to 6-membered heteroaryl; provided that -Q2-T2 is not H; and R7 is C1-C6 alkyl, C3-C8 cycloalkyl or 4 to 7-membered heterocycloalkyl, each optionally substituted with one or more -Q5-T5, wherein Q5 is a bond, C(O), or C1-C3 alkyl linker, and T5 is H, halo, C1-C6 alkyl, hydroxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, or 5 to 6-membered heteroaryl and T5 is optionally substituted with one or more substituents selected from the group consisting of halo, C1-C6 alkyl, hydroxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, and 5 to 6-membered heteroaryl except when T5 is H, halo, hydroxyl, or cyano; or -Q5-T5 is oxo;
provided that the compound is notN-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(2,5-dimethylthiophen-3-yl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide,6-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide,or6-cyclopropyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide. |
