Multi-indication mRNA cancer immunotherapy

摘要

Synthetic bacterial messenger RNA can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mRNA obtained from DNA that encodes an immunogenic bacterial protein. An immune response to the cancer is generated from direct administration of the mRNA in vivo or administration of vaccines prepared from cancer cells in vitro.

主权项

1. A method of treating a cancer patient, comprising administering a ribonucleic acid having the sequence of SEQ ID NO: 1 directly into a tumor or tumor draining lymph node of a cancer patient.