| 发明名称 | Compositions and methods for the treatment of retinal degeneration | ||
| 摘要 | The present invention relates to a pharmaceutical composition comprising an inhibitor of eIF2α, a compound increasing the expression and/or activity of protein BiP and/or an inhibitor of Caspase-12, preferably an inhibitor of eIF2α and a compound increasing the expression and/or activity of protein BiP. The present invention also relates to pharmaceutical compositions and methods for treating retinal degeneration related to ciliary dysfunction. | ||
| 申请公布号 | US9636377(B2) | 申请公布日期 | 2017.05.02 |
| 申请号 | US201314380493 | 申请日期 | 2013.02.25 |
| 申请人 | UNIVERSITE DE STRASBOURG | 发明人 | Marion Vincent;Mockel Anaïs;Dollfus Hélène |
| 分类号 | A61K38/07;A61K31/19;A61K45/00;A61K31/155;A61K45/06;A61K38/22;A61K38/55 | 主分类号 | A61K38/07 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A method of treating retinal degeneration induced by Bardet-Biedl syndrome or by Leber's congenital amaurosis caused by mutation in a ciliary gene, the method comprising administering guanabenz and valproic acid to a subject having retinal degeneration induced by Bardet-Biedl syndrome or by Leber's congenital amaurosis caused by mutation in a ciliary gene. | ||
| 地址 | Strasbourg FR | ||