| 主权项 |
1. A ready to use, multi-dose liquid pharmaceutical composition suitable for injection, comprising:
(i) a liquid formulation comprising a non-volatile sugar acid, and carfilzomib or a pharmaceutically acceptable salt thereof; (ii) wherein the liquid formulation comprises a solvent system suitable for injection and including at least one of ethanol, propylene glycol, polyethylene glycol, and water; (iii) wherein the weight ratio of the non-volatile sugar acid to the carfilzomib or the pharmaceutically acceptable salt thereof ranges from 2:1 to 15:1; liquid formulation is present in a container in a quantity suitable for at least two independent and distinct administrations; and (iv) wherein the liquid formulation is formulated to maintain degradation of the carfilzomib or the pharmaceutically acceptable salt thereof at a level of less than 10% when the liquid formulation is stored over at least one month at 25 degrees Celsius and 60% relative humidity. |
