发明名称 Vitamin functionalized gel-forming block copolymers for biomedical applications
摘要 Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
申请公布号 US9637592(B2) 申请公布日期 2017.05.02
申请号 US201615343537 申请日期 2016.11.04
申请人 International Business Machines Corporation;Agency For Science, Technology And Research 发明人 Hedrick James L.;Lee Ashlynn L. Z.;Ng Victor W. L.;Yang Yi Yan
分类号 A61K47/34;C08G64/18;A61K47/48 主分类号 A61K47/34
代理机构 代理人 Roberts Michael R.
主权项 1. A gel-forming block copolymer having a structure in accordance with formula (1):wherein d′ is a positive number having a value of about 100 to about 600, each K′ is an independent divalent linking group selected from the group consisting of O, NH, S, and combinations thereof, each Pa is an independent monocarbonate or polycarbonate chain comprising 1 to about 10 vitamin-bearing subunits, wherein each of the vitamin-bearing subunits comprises a carbonate backbone portion and a side chain linked to the carbonate backbone portion, the side chain comprising a covalently bound form of a vitamin, Za is a first end group selected from the group consisting of hydrogen and groups comprising 1 to about 15 carbons, and Zb is a second end group selected from the group consisting of hydrogen and groups comprising 1 to about 15 carbons.
地址 Armonk NY US