| 发明名称 | Monoclonal antibodies for detection of folate receptor 1 | ||
| 摘要 | The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided. | ||
| 申请公布号 | US9637547(B2) | 申请公布日期 | 2017.05.02 |
| 申请号 | US201414473828 | 申请日期 | 2014.08.29 |
| 申请人 | ImmunoGen, Inc. | 发明人 | Ab Olga;Tavares Daniel;Setiady Julianto;Ladd Sharron;Carrigan Christina N.;Rui Lingyun |
| 分类号 | C07K16/30;A61K47/48;G01N33/574;C07K16/28;A61K39/00 | 主分类号 | C07K16/30 |
| 代理机构 | Sterne, Kessler, Goldstein & Fox P.L.L.C. | 代理人 | Sterne, Kessler, Goldstein & Fox P.L.L.C. |
| 主权项 | 1. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to the same folate receptor 1 (FOLR1) epitope as an antibody comprising a heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:27 and a light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:28, wherein the monoclonal antibody or antigen-binding fragment thereof binds to an epitope of FOLR1 comprising an N-glycosylated amino acid. | ||
| 地址 | Waltham MA US | ||