HER3 antibodies and uses thereof

摘要

Provided herein are antibodies specific for HER3. Also provided are methods of treating cancer in a subject comprising administering an effective amount of the antibodies described herein to the subject.

主权项

1. An antibody specific for HER3, wherein the antibody does not block ligand binding and wherein the antibody blocks phosphorylation of HER3, wherein the antibody comprises a light chain with polypeptide sequences comprising SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:5 and a heavy chain with polypeptide sequences comprising SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8.