Virus like particle comprising PD-1 antigen or PD-1 ligand antigen

摘要

The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.

主权项

1. A virus-like particle comprising a virus structural protein of an alphavirus or a flavivirus, and an antigen selected from the group consisting of (a)-(c):
(a) an antigen which comprises a 10-300 amino acid fragment of human Programmed Death-1 (PD-1), or which comprises an amino acid sequence having at least 90% amino acid identity to said fragment of human PD-1; (b) an antigen which comprises a 10-300 amino acid fragment of human Programmed Death-Ligand 1 (PD-L1), or which comprises an amino acid sequence having at least 90% amino acid identity to said fragment of human PD-L1; and (c) an antigen which comprises a 10-300 amino acid fragment of human Programmed Death-Ligand 2 (PD-L2), or which comprises an amino acid sequence having at least 90% amino acid identity to said fragment of human PD-L2.