Heterocyclic compounds as inhibitors of class I PI3KS

摘要

The present application discloses a novel class of heterocycles as class I PI3Ks inhibitors. The compounds claimed herein could be used alone or in combination therapies for the treatment of a wide range of disorders such as autoimmune, inflammatory and allergic diseases, asthma, COPD, parasitic infections, diabetes, and cancer.

主权项

1. A compound having the structure of formula (I): wherein: X is selected from: —CH2CH2—, —CH═CHCH2— or —CH2CH2CH2—; Z is hydrogen; R1 is selected from: phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, piperidine, morpholine, or phenyl which is substituted by at least one substituent selected from: deuterium, —CH3, —OCH3, —OCF3, or —F; R2 and R3 are independently selected from: hydrogen, deuterium, C1-C6 alkyl, or halogen; Y is selected from:or a pharmaceutically acceptable salt thereof.