6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection

摘要

The invention provides novel compounds having the general formula:;
wherein R1 to R6, W and X are as described herein and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

主权项

1. A compound of formula (I)wherein
R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, C1-6alkyl, diC1-6alkylamino, cyano, N-containing monocyclic heterocycloalkyl and OR7, wherein R7 is hydrogen; C1-6alkyl; or C1-6alkyl which is substituted one or more times by fluoro, C3-7cycloalkyl, phenyl, hydroxyl, amino, C1-6alkoxy, C1-6alkylsulfanyl, C1-6alkylsulfonyl, diC1-6alkylamino, C1-6alkoxycarbonylamino, monocyclic heterocycloalkyl, pyrazoyl or imidazolyl; R5 is hydrogen or C1-6alkyl; R6 is hydrogen, C1-6alkyl, phenyl-CxH2x—, C1-6alkylcarbonyl, C1-6alkylsulfonyl, benzoyl or monocyclic heterocycloalkyl, wherein x is 1-6; W is a bond, CyH2yC(R8)(R9)CzH2z or CyH2yCH(R8)CH(R9)CzH2z, wherein R8 and R9 are independently selected from the group consisting of hydrogen, fluoro, hydroxy and C1-6alkyl, y is 0-6; z is 0-6; X is a bond; O; S; S(O)2; or NR10, wherein R10 is hydrogen or C1-6alkyl; or R6 and R10, together with the nitrogen to which they are attached, form monocyclic heterocycloalkyl; with the proviso that when X is a bond, R6 is not hydrogen, C1-6alkyl or phenyl-CxH2x—; or a pharmaceutically acceptable salt, enantiomer, or diastereoisomer thereof.