| 发明名称 | Anti-sPLA2-IIA antibodies and uses thereof | ||
| 摘要 | The present invention relates to antibodies anti-sPLA2-IIA and uses thereof. | ||
| 申请公布号 | US9637553(B2) | 申请公布日期 | 2017.05.02 |
| 申请号 | US201314387430 | 申请日期 | 2013.03.22 |
| 申请人 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE NICE SOPHIA ANTIPOLIS | 发明人 | Lambeau Gerard;Valentin Emmanuel;Rennou Melanie |
| 分类号 | C07K16/40;G01N33/53;C12N5/16;C12N15/63;G01N33/573;C07K14/47 | 主分类号 | C07K16/40 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. An isolated antibody comprising a variable region of a heavy chain and a variable region of a light chain, wherein: the variable region of the heavy chain comprises the following CDRs: GYTFTS (SEQ ID NO: 1), WIFPGDGSTE (SEQ ID NO: 2) and WGITAFPLFDY (SEQ ID NO: 3); the variable region of the light chain comprises the following CDRs: RASESVDYDGDSYMN (SEQ ID NO: 4), AASNLES (SEQ ID NO: 5) and LQSNEAPWT (SEQ ID NO: 6); and wherein said antibody has a dissociation constant (Kd) for binding to human secretory phospholipase A2 IIA (sPLA2-IIA) less than 9×10−10 M. | ||
| 地址 | Paris FR | ||