| 发明名称 |
Process for producing influenza vaccine |
| 摘要 |
A process for producing a split influenza virus preparation or subunit influenza preparation comprising the steps of: (i) providing a whole virus preparation; (ii) splitting the whole virus preparation in the presence of a first detergent; (iii) adding t-octylphenoxypolyethoxyethanol (TRITON X-100™) to the resulting split virus preparation; and (iv) filtering the split virus preparation. |
| 申请公布号 |
US9636394(B2) |
申请公布日期 |
2017.05.02 |
| 申请号 |
US201013503859 |
申请日期 |
2010.10.25 |
| 申请人 |
GLAXOSMITHKLINE BIOLOGICALS SA;GLAXOSMITHKLINE BIOLOGICALS, NIEDERLASSUNG DER SMITHKLINE BEECHAM PHARMA GMBH & CO KG. |
发明人 |
D'Hondt Erik Jozef;Engelmann Hans Bernd |
| 分类号 |
A61K39/145;C12N7/00;A61K39/12;A61K39/00 |
主分类号 |
A61K39/145 |
| 代理机构 |
|
代理人 |
Lissy Natalie A. |
| 主权项 |
1. A process for producing a split monovalent influenza virus preparation or subunit influenza preparation comprising the steps of: (i) providing a whole virus preparation; (ii) splitting the whole virus preparation in the presence of a first detergent, wherein the first detergent is not t-octylphenoxypolyethoxyethanol, thereby producing a split virus preparation; (iii) adding t-octylphenoxypolyethoxyethanol to the split virus preparation, wherein t-octylphenoxypolyethoxyethanol is present in an amount of 0.1-0.4% (w/v); and (iv) filtering the split virus preparation in the presence of t-octylphenoxypolyethoxyethanol. |
| 地址 |
Rixensart BE |
