Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion

摘要

An ophthalmic solution is provided. The ophthalmic solution is hypertonic. The ophthalmic solution includes a polysaccharide having an average molecular weight of between about 40,000 grams per mole and about 150,000 grams per mole. A packaged ophthalmic solution for preventing the ophthalmic solution from being exposed to CO2 and other contaminants is also provided. The ophthalmic solution can be used to treat recurrent corneal erosion. The ophthalmic solution can also be used as a prophylactic to prevent recurrent corneal erosion.

主权项

1. An ophthalmic solution for treating and preventing recurrent corneal erosion consisting essentially of:
between about 5% and 25% by weight of non-substituted glucose polymer having an average molecular weight of between about 40,000 grams per mole and about 150,000 grams per mole; between about 0.5% and 2% by weight NaCl; between about 0.5% and 2% by weight hyaluronic acid; between about 71% and 94% by weight H2O; and optionally an anesthetic; wherein the ophthalmic solution is an aqueous solution having a viscosity of between about 6.5 and 7.5 centistokes, has a pH between about 6.5 and 7.5, has an osmolality of between about 320-350 mOsmol/kg solution and a colloidal osmolality at least equal to the colloidal osmolality of the deturgescent cornea.