Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors

摘要

The invention provides novel compounds having the general formula (I);
wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 and n are as described herein, compositions including the compounds and methods of using the compounds.

主权项

1. A Compound of formula (I) wherein R1, R2, R3, R4 and R5 are independently selected from H, halogen, cyano, nitro, alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy and cycloalkoxy; R6 is H, alkyl, haloalkyl, cycloalkyl, substituted aryl or substituted heteroaryl, wherein substituted aryl or substituted heteroaryl are substituted with R18, R19 and R20; R7, R8, R9, R10, R11 and R12 are independently selected from H, halogen, alkyl and haloalkyl; A1 is —(CR14R15)p—C(O)NR16R17 or —(CR14R15)p—C(O)OR17; R14 and R15 are independently selected from H, alkyl, haloalkyl, cycloalkyl and halocycloalkyl; R16 is H, alkyl, haloalkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl or haloalkoxyalkyl; R17 is H, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, cycloalkoxyalkyl, substituted aryl or substituted heteroaryl, wherein substituted aryl and substituted heteroaryl are substituted with R21, R22 and R23; or R16 and R17 together with the nitrogen to which they are attached form a substituted heterocycloalkyl or a substituted heteroaryl, wherein substituted heterocycloalkyl and substituted heteroaryl are substituted with R21, R22 and R23; R18, R19, R20, R21, R22 and R23 are independently selected from H, halogen, alkyl, haloalkyl, cycloalkyl, alkoxy and haloalkoxy; n is zero, 1 or 2; p is zero, 1 or 2; and pharmaceutically acceptable salts thereof.