| 主权项 |
1. A process for increasing the crystallinity of a crystallizable solid, comprising contacting said crystallizable solid with a non-solvent; and
applying ultrasound to the crystallizable solid when in contact with said non-solvent; wherein the crystallizable solid is selected from the group consisting of an active pharmaceutical ingredient, an active agrochemical ingredient, a pharmaceutical excipient, an agrochemical excipient and appropriate mixtures of two or more thereof; and wherein the process further comprises: (i) forming a solution of the crystallizable solid in a solvent; (ii) subjecting the solution, after step (i), to a process selected from the group consisting of rapid precipitation, freeze drying, lyophilisation, rapid expansion of supercritical solutions, spray drying or mixtures thereof, wherein the said dissolved crystallizable solid is converted into a substantially dry solid material; (iii) isolating, after step (ii), the substantially dry crystallizable solid from the liquid and/or gaseous components of the process of step (ii); (iv) treating, after step (iii), said substantially dry crystallizable solid from step (iii) with a non-solvent therefor; (v) applying ultrasound, after step (iv), to the crystallizable solid from step (iv) when it is in contact with said non-solvent; and (vi) optionally, after step (v), separating and/or drying the resultant crystallizable solid from step (v). |
