Beta-lactamase inhibitors

摘要

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

主权项

1. A compound of Formula (IIa) or a pharmaceutically acceptable salt, tautomer, or N-oxide thereof: wherein: M is hydrogen, —CN, —C(O)—R4, or optionally substituted alkynyl; each R1 and R2 are hydrogen; n is 0, 1, 2, 3, 4, 5, or 6; X1 is —OR4 or F; R3 is —R30OC(O)R31 or —R30OC(O)OR31; R30 is —CH2— or —CH(CH3)—; R31 is optionally substituted C1-C12 alkyl, aryl, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl; Ra, Rb, and Rc are independently hydrogen, fluoro, chloro, optionally substituted C1-C6 alkyl, —OR4, —NR4R5, or —SR4; Rd, R4 and R5 are independently hydrogen or C1-C6 alkyl.