Antiviral compounds and uses thereof

摘要

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

主权项

1. A compound or salt thereof, wherein:
the compound corresponds in structure to formula (I-L0): R1 is selected from the group consisting of: and benzoyl; n is selected from the group consisting of 1, 2, and 3; R15 is selected from the group consisting of hydrogen, amino, and amino substituted with alkoxycarbonyl; m is selected from the group consisting of 0, 1, 2, and 3; R16 is selected from the group consisting of hydrogen, aryl, alkyl, and alkyloxycarbonyl; R2 is selected from the group consisting of alkyl and 5-6-membered heterocyclyl, wherein:
(a) the alkyl optionally is substituted with one or more halo, and(b) the heterocyclyl optionally is substituted with up to three substituents independently selected from the group consisting of alkyl and oxo; R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy, alkynyloxy, amino, and halo; R4 is a fused 2-ring carbocyclyl optionally substituted with one or more substituents independently selected from the group consisting of RE, RF, and RJ; each RE is independently selected from the group consisting of hydroxy and oxo; each RF is C1-C6alkyl optionally substituted with one or more amino, wherein the amino optionally is substituted with one or two C1-C6alkylsulfonyl, wherein the amino portion of the alkylsulfonylamino optionally is substituted with C1-C6alkyl; and each RJ is C1-C6alkylsulfonylamino.