| 发明名称 |
2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors |
| 摘要 |
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy. |
| 申请公布号 |
US9637456(B2) |
申请公布日期 |
2017.05.02 |
| 申请号 |
US201414770499 |
申请日期 |
2014.03.12 |
| 申请人 |
GlaxoSmithKline Intellectual Property (No. 2) Limited |
发明人 |
Amans Dominique;Atkinson Stephen John;Harrison Lee Andrew;Hirst David Jonathan;Law Robert Peter;Lindon Matthew;Preston Alexander;Seal Jonathan Thomas;Wellaway Christopher Roland |
| 分类号 |
C07D215/44;C07D401/12;A61K31/4709;A61K31/506;C07D401/14;C07D405/14;C07D413/14;C07D215/227;C07D215/46;C07D215/48;C07D401/04;C07D405/04;C07D409/12;C07D409/14;C07D413/04;C07D413/12;C07D417/12;C07D417/14;C07D471/04;C07D471/08;C07D487/08;C07D498/04;A61K31/4375;A61K31/4706;A61K31/496;A61K31/497;A61K31/5377;A61K31/5386;C07D498/08 |
主分类号 |
C07D215/44 |
| 代理机构 |
|
代理人 |
Fitch Duke M.;Lutomski Kathryn A.;Gimmi Edward R. |
| 主权项 |
1. A compound which is (2S,3R,4R)-1-acetyl-2-cyclopropyl-3-methyl-4-((4-methylpyrimidin-2-yl)amino)-1,2,3,4-tetrahydroquinoline-6-carboxamide, represented by the formula: or a salt thereof. |
| 地址 |
Brentford, Middlesex GB |
