| 主权项 |
1. An interferometric detection system comprising:
a. a substrate; b. a channel formed in the substrate for reception of a sample to be analyzed; c. one or more marker compounds, wherein each of the one or more marker compounds is positioned in one of a plurality of discrete zones along a length of the channel; d. a light source for generating a light beam, the light beam having a width and being dispersed and collimated in a direction parallel to a longitudinal axis of the channel and along a direction of sample flow within the channel to an extent greater than the natural divergence of the light beam, the light source being positioned to direct the light beam onto the substrate such that the light beam is incident on at least a portion of each of two or more of the plurality of discrete zones within the same channel such that the intensity of the light on each of at least two zones is the same or substantially the same, wherein a portion of the light beam adjacent to the substrate has a width greater than the width of the light beam at the light source, at least one of the discrete zones containing the one or more marker compounds, to thereby generate scattered light through reflective and refractive interaction of the light beam with a substrate/channel interface, the sample, and at least a portion of the one or more marker compounds, the scattered light comprising interference fringe patterns elongated in at least one direction, wherein the interference fringe patterns shift in response to changes in the refractive index of the sample; e. a photodetector for receiving scattered light from each of the two or more discrete zones and generating a plurality of intensity signals; and f. at least one signal analyzer for receiving the intensity signals and determining therefrom one or more characteristic properties of the sample at one or more of the discrete zones along the length of the channel. |
