PHOSPHORESCENT TRANSITION METAL COMPLEX, ITS PREPARATION AND USE

摘要

A phosphorescent transition metal complex especially suitable as sensor for hydrogen peroxide in cells, in particular in mitochondria in live cells, includes a metallic central atom, which is a transition metal, a first ligand with at least one pyridine ring, and a second ligand having at least one pyridine ring and at least one structural component selected from the group of 1,2-diketone moiety and an arylboronate moiety. A method for preparing the metal complex is also disclosed as well as a method of detecting hydrogen peroxide in cells by incubating cells with the transition metal complex. The metal complex shows advantageous intense and long-lived phosphorescence accompanied by exceptional cellular localization properties. The metal complex is highly photostable and highly selective towards hydrogen peroxide, thus, especially suitable for detecting mitochondrial H2O2.

主权项

1. A phosphorescent metal complex comprising:
a metallic central atom selected from a transition metal; a first ligand comprising at least one pyridine ring, wherein the nitrogen atom of said pyridine ring is coordinated to the metallic central atom; a second ligand comprising at least one pyridine ring and at least one structural component selected from the group of 1,2-diketone moiety and an arylboronate moiety, wherein the nitrogen atom of said pyridine ring is coordinated to the metallic central atom.