| 发明名称 |
METHODS FOR PREDICTING THE RADIOSENSITIVITY OF A CANCER TUMOR AND METHODS OF TREATING CANCER |
| 摘要 |
Methods for predicting the radiosensitivity of a cancer tumor and treating cancer in a subject are provided. In another aspect, methods of treating cancer in a subject are also provided. The methods may include administering to the subject radiation therapy based on the expression level of no more than 35, 30, 25, 20, 15, 10, or 5 biomarkers in a tumor sample from the subject. The methods of treating cancer in a subject may also include administering a therapeutically effective amount of a FAS agonist and/or a TNFRSF10B agonist to the subject, and administering radiation therapy to the subject. |
| 申请公布号 |
US2017115293(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201615331416 |
申请日期 |
2016.10.21 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
Horton Janet;Chi Jen-Tsan Ashley;Reihani Sharareh;Dewhirst Mark W. |
| 分类号 |
G01N33/574;C07K16/28;A61N5/10;C12Q1/68 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method comprising:
i) obtaining a tumor sample from a subject, ii) measuring the expression level of no more than 25 biomarkers in the sample, wherein the biomarkers comprise at least one biomarker selected from FAS, TNFRSF10B, CD48, LST1, LY86, CCR1, LY96, AIF1, TNFSF13B, TP5313 (p53-inducible protein 3) and caspase 9. |
| 地址 |
Durham NC US |
