发明名称 QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES
摘要 The present invention relates to the use of quinazolines of formula (I),;;wherein the groups Ra to Rd have the meanings given in the claims and specification, in cancer therapy.
申请公布号 US2017112835(A1) 申请公布日期 2017.04.27
申请号 US201615338632 申请日期 2016.10.31
申请人 Boehringer Ingelheim International GmbH 发明人 SOLCA Flavio;AMELSBERG Andree;van MEEL Jacobus C.A.;BAUM Anke;STEHLE Gerd
分类号 A61K31/517 主分类号 A61K31/517
代理机构 代理人
主权项 1. A method for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) wherein Ra denotes a benzyl, 1-phenylethyl or 3-chloro-4-fluorophenyl group, Rb denotes a hydrogen atom or a C1-4-alkyl group, Rc denotes a cyclopropylmethoxy, cyclobutyloxy, cyclopentyloxy, tetrahydrofuran-3-yl-oxy, tetrahydrofuran-2-yl-methoxy, tetrahydrofuran-3-yl-methoxy, tetrahydropyran-4-yl-oxy or tetrahydropyran-4-yl-methoxy group, Rd denotes a dimethylamino, N-cyclopropyl-N-methyl-amino, N-cyclopropylmethyl-N-methyl-amino, N-ethyl-N-methyl-amino, N,N-diethylamino, N-isopropyl-N-methyl-amino, N-(2-methoxyethyl)-N-methyl-amino, N-(1-methoxy-2-propyl)-N-methyl-amino, N-(3-methoxypropyl)-N-methyl-amino, pyrrolidino, 2-methylpyrrolidino, 2-(methoxymethyl)-pyrrolidino, morpholino, (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, (1R,4R)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, N-cyclopropyl-N-methyl-amino-, N-methyl-N-(tetrahydrofuran-3-yl)-amino, N-methyl-N-(tetrahydrofuran-2-ylmethyl)-amino, N-methyl-N-(tetrahydrofuran-3-yl-methyl)-amino, N-methyl-N(tetrahydropyran-4-yl)-amino or N-methyl-N-(tetrahydropyran-4-yl-methyl)-amino group, or a group of formula (II) wherein Re and Rf, which may be identical or different, in each case denote a hydrogen atom or a C1-3-alkyl group, to a patient in need thereof,
地址 Ingelheim am Rhein DE