发明名称 |
DIRECTLY COMPRESSIBLE GRANULAR MICROCRYSTALLINE CELLULOSE BASED EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF |
摘要 |
An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API. |
申请公布号 |
US2017112768(A1) |
申请公布日期 |
2017.04.27 |
申请号 |
US201715398207 |
申请日期 |
2017.01.04 |
申请人 |
AVANTOR PERFORMANCE MATERIALS, LLC |
发明人 |
DEORKAR Nandu;FARINA James;MIINEA Liliana;RANDIVE Sameer |
分类号 |
A61K9/16;A61K31/192;B01J2/04;A61K9/28;B29C43/00;A61K9/20;A61K31/40 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising:
about 90% to about 99% microcrystalline cellulose; and about 1% to about 10% at least one binder; wherein the microcrystalline cellulose and binder are indistinguishable when viewed with a SEM, thereby forming substantially homogeneous-particles. |
地址 |
Center Valley PA US |