HETERO FUNCTIONAL BINDING SYSTEMS

摘要

The present invention relates to reagents and methods for binding compounds to surfaces that are hydrophobic. More specifically, the invention relates to simple methods for coating of hydrophobic planar, membrane or particle surfaces to facilitate binding of molecules such as labels, dyes, synthetic and biological polymers and/or nanoparticles thereto.

主权项

1. A modified substrate for binding of a target molecule thereon, the substrate including:
a surface that is hydrophobic, and a metal complex including a metal ion, the metal ion having:
(i) one or more co-ordination sites occupied by a hydrophobic ligand for binding the metal complex to the hydrophobic surface, and(ii) one or more co-ordination sites available for binding to a target molecule,wherein the hydrophobic ligand binds to the hydrophobic surface by non-covalent and non-coordinative interactions such that the co-ordination sites available for binding to a target molecule are directed away from the hydrophobic surface.