发明名称 |
One-Step Labeling of Antibodies to High Specific Activity with Actinium-225 |
摘要 |
Provided herein is a one-step method for chelating actinium-225 to a construct comprising a chelator linked to a bio-molecule, such as, an antibody or monoclonal antibody, via a bifunctional ligand in, for example, a 3-arm configuration. Also provided are methods for increasing the radiochemical yield of an actinium-225-chelant-biomolecule complex and for producing a high specific activity actinium-225 complex. The chelation is performed at a physiological temperature, about 37° C. Also provided are high specific activity actinium-225 complexes, that is, actinium-225 chelated to the chelator-biomolecule construct and pharmaceutical compositions thereof. Further provided are methods of treating a neoplastic disease or disorder with the actinium-225 complexes. |
申请公布号 |
US2017112951(A1) |
申请公布日期 |
2017.04.27 |
申请号 |
US201515311721 |
申请日期 |
2015.05.18 |
申请人 |
Scheinberg David A.;Smith-Jones Peter M.;McDevitt Michael R.;Maquire William F. |
发明人 |
Scheinberg David A.;Smith-Jones Peter M.;McDevitt Michael R.;Maquire William F. |
分类号 |
A61K51/10;C07K16/32;C07K16/28 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
1. A one-step chelation process for actinium-225, comprising:
chelating, under physiological conditions, actinium-225 to a chelator construct comprising a bifunctional ligand conjugated to said chelator in a 3-arm configuration and covalently linking a biomolecule thereto. |
地址 |
New York NY US |