| 主权项 |
1. A humanized anti-BRDU antibody, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 01, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 04, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, further comprising (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 06, (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08,
wherein the antibody comprises
P at position 30 of the heavy chain variable domain, andF at position 58 of the heavy chain variable domain, andT at position 108 of the heavy chain variable domain, andK at position 49 of the light chain variable domain, andL at position 98 of the light chain variable domain (all positions according to Kabat). |
