发明名称 |
THERAPEUTIC AGENTS FOR REDUCING PARATHYROID HORMONE LEVELS |
摘要 |
Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis. |
申请公布号 |
US2017114095(A1) |
申请公布日期 |
2017.04.27 |
申请号 |
US201715402133 |
申请日期 |
2017.01.09 |
申请人 |
KAI Pharmaceuticals, Inc. |
发明人 |
Karim Felix;Baruch Amos;Maclean Derek;Das Kanad;Yin Qun |
分类号 |
C07K7/06 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
1. A peptide comprising the amino acid sequence X1-X2-X3-X4-X5-X6-X7,
wherein: X1 is a subunit comprising a thiol-containing group; X5 is a cationic subunit; X6 is a non-cationic subunit; X7 is a cationic subunit; and at least one of X2, X3 and X4 is independently a cationic subunit. |
地址 |
South San Francisco CA US |