| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is H or C1-6 alkyl; R2 is R, —(CH2)n-phenyl, —C(O)R, —SO2R, or —C(O)N(R)2; n is 0, 1, or 2; each R is independently hydrogen, —CN, or an optionally substituted group selected from saturated or unsaturated C1-6 aliphatic, phenyl, 4-7 membered saturated or partially unsaturated monocyclic carbocyclic ring, 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms, or a 4-8 membered saturated or partially saturated heterocyclic ring with 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R3 is Ring A, —C(O)R, —C(O)OR, —C(O)N(R)2, —SO3H, —SO2N(R)2, —S(O)R, —S(O)Ring A, —OR or —B(OR)2 where two OR groups on the same boron are taken together with their intervening atoms to form a 5-8 membered monocyclic saturated or partially unsaturated, ring having 0-3 heteroatoms, in addition to the boron and two oxygens, independently selected from nitrogen, oxygen, or sulfur or R3 and R4 taken together form an optionally substituted 5-6 membered ring having 0-1 heteroatoms selected from nitrogen, oxygen or sulfur; L is a covalent bond or a straight or branched C1-6 alkylene chain optionally substituted with 1-9 fluoro groups; Ring A is an optionally substituted ring selected from phenyl or an optionally substituted 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; R4 is R, —CF3, —OR, —N(R)2, —Si(R)3, or —SR or R3 and R4 taken together form an optionally substituted 5-6 membered ring having 0-1 heteroatoms selected from nitrogen, oxygen or sulfur; and R is H or C1-4 alkyl, wherein said compound of formula I is other than those depicted in Table 2. |
