HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

摘要

Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.;

主权项

1. A compound of formula (I), formula (II), or formula (III): wherein Ar is optionally substituted C6-C14 aryl, X is O or S, R1 is hydrogen, C1-C6 alkyl, or CF3, A is wherein n is an integer of 1 to 3, o is 0 or 1, Y is CR9R10 or O, R2 and R3 are independently C1 or C2 alkyl, R4 is di(C1-C6 alkylamino)C2-C6 alkyl or a 5- or 6-membered N-containing heterocyclic ring, and R5-R14 are independently hydrogen or C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.