NOVEL ORGANOSELENIUM COMPOUNDS, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL USES THEREOF IN PARTICULAR AS ANTITUMOR AGENTS

摘要

The invention relates to a selenium compound. Said selenium compound has formula (I), where R1=alkyl; R2=H, R4C(=0), R4OC(=0), a-aminoacyl, CH3SeCH2CH2CH(NH2)C(=0), CH3SeCH2CH2CH(OH)C(=0); X=OH, OR3, NH2, NR4R5, α-amino acid, CH3SeCH2CH2CH(COOH)NH—, CH3SeCH2CH2CH(COOH)0-; R3=alkyl; R4=alkyl, aryl; R5=H, alkyl, aryl; R4 and R5 which can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R2≠C(=0)CH3. Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.

主权项

1. A selenium compound having the following general formula (I):where
R1=alkyl; R2=H, R4C(═O), R4OC(═O), α-aminoacyl, CH3SeCH2CH2CH(NH2)C(═O), CH3SeCH2CH2CH(OH)C(═O); X=OH, OR3, NH2, NR4R5, α-amino acid, CH3SeCH2CH2CH(COOH)NH—, CH3SeCH2CH2CH(COOH)O—; R3=alkyl; R4=alkyl, aryl; R5=H, alkyl, aryl; R4 and R5 being capable of forming together a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that, when X=NH-tert-butyl, R2≠C(═O)CH3, as well as all the stereoisomers, diastereoisomers and enantiomers in particular with respect to the carbon atom bearing the group OR2, as well as with respect to the radicals R1 to R5, as well as all oligomers (dimers, trimers, . . . ) and polymers, linear or branched, acyclic or cyclic, obtained between two or more molecules of derivatives of formula (I) described in the invention by esterification reaction between the alcohol and carboxylic acid functions present if applicable, considered alone or in a mixture; as well as all the salts of pharmaceutically acceptable acids or bases of said compounds of general formula (I); as well as the salts of sodium, calcium, zinc and magnesium.