| 发明名称 |
Conjugates Comprising an Anti-EGFR1 Antibody |
| 摘要 |
The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula —O—(CH2)n—S—B12H112− wherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof. |
| 申请公布号 |
US2017112931(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201515318030 |
申请日期 |
2015.06.12 |
| 申请人 |
Tenboron Oy |
发明人 |
Leppanen Anne;Ekholm Filip S.;Helin Jari;Salo Hanna;Kanerva Anne |
| 分类号 |
A61K41/00;C07K16/30;C07K14/245;A61K31/721;C07K16/28 |
主分类号 |
A61K41/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A conjugate comprising an anti-EGFR1 antibody or an EGFR1 binding fragment thereof and at least one dextran derivative, wherein
the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula
—O—(CH2)n—S—B12H112− wherein n is in the range of 3 to 10; and the dextran derivative is bound to the anti-EGFR1 antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof. |
| 地址 |
Helsinki FI |
