| 发明名称 |
CELL DELIVERY SYSTEM AND METHOD |
| 摘要 |
The present invention is directed to a cell delivery system for the delivery of materials including nucleic acids across a biological barrier and methods of use thereof. The cell delivery system of the invention comprises a microprotrusion array composed of a swellable and/or dissolvable polymer composition for use in the transport of a material across a biological barrier, wherein the material comprises nanoparticles formed from a nucleic acid complexed with an amphipathic cell penetrating peptide and wherein the microprotrusion array is loaded with the nanoparticles. |
| 申请公布号 |
US2017112760(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201515317786 |
申请日期 |
2015.06.09 |
| 申请人 |
The Queen's University of Belfast |
发明人 |
McCarthy Helen;Donnelly Ryan;McCaffrey Joanne |
| 分类号 |
A61K9/00;A61K48/00;A61K47/10;A61K31/713;A61K39/00;A61K31/663;A61K47/32;A61K47/34;A61K39/12;C12N7/00;A61K39/39;C12N15/113 |
主分类号 |
A61K9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cell delivery system comprising
a microprotrusion array for use in the transport of a material across a biological barrier in which the array comprises a plurality of microprotrusions composed of a swellable and/or dissolvable polymer composition; the material comprises nanoparticles formed from a nucleic acid or a negatively charged or hydrophilic compound complexed with an amphipathic cell penetrating peptide; wherein the microprotrusion array is loaded with the nanoparticles. |
| 地址 |
Belfast Antrim GB |
