| 摘要 |
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided. |
| 主权项 |
1. A compound having the formula: or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein, X1 and X2 are independently selected from the group consisting of hydrogen, halogen, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, C1-C4 haloalkyl, cyclopropyl, and CONH2; and when X1 and X2 are on adjacent vertices of the phenyl ring they are optionally joined together to form an optionally substituted 5- or 6-member aromatic or aliphatic ring containing 0, 1, or 2 heteroatoms; and R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C3-C8 cycloalkyl-C1-C4 alkyl, optionally substituted 3- to 7-membered cycloheteroalkyl, optionally substituted C1-C4 haloalkyl, hydroxyl, optionally substituted aryl, and optionally substituted heteroaryl; and R1 and R2 are optionally joined together to form an optionally substituted C3-C8 cycloalkyl or optionally substituted 3- to 7-membered cycloheteroalkyl with the proviso that R1 and R2 do not join together to form an unsubstituted cyclohexane ring, and at least one of R1 and R2 is other than hydrogen. |
