Intranasal administration of agents with pro-inflammatory activity for the therapy of neurological disorders

摘要

The invention concerns a product consisting of distilled water or of an aqueous solution hypotonic or substantially isotonic with respect to blood plasma or, less preferably, hypertonic with respect to blood plasma, to be administered on the nasal mucosa according to a specific operation mode in order to cause an inflammation of an irritative kind, for use in a treatment of stimulation of the endogenous production of inflammatory mediators, in the therapy and prevention of neurological disorders, in particular of degenerative disorders of the central and peripheral nervous system. The inflammatory mediators the endogenous production of which is stimulated comprise NGF, neurotrophin-3, neurotrophin-4, serotonin, substance P, heparin, ECF-A.

主权项

1. A method for therapy and prophylaxis of at least one pathology selected from the group consisting of pathologies of the central nervous system, pathologies of the peripheral nervous system and neurologic pathologies of the auditory, visual and olfactory apparatus, comprising
selecting a water-based liquid having an osmolality not higher than 130% of a blood plasma osmolality; and stimulating endogenous production of at least one inflammatory mediator selected from the group consisting of NGF, neurotrophin-3, neurotrophin-4, serotonin, substance P, heparin, and ECF-A by administering the selected water-based liquid on a nasal-paranasal mucous membrane of the subject; wherein the administration on the nasal-paranasal mucous membrane is carried out by dispensing an amount of the water-based liquid at a dispensing rate (PEL) ranging from 5.0 g/sec to 15 g/sec, for a dispensing time (ET) ranging from 0.4 sec to 120 sec, with the proviso that a mathematical product of ET and PEL is no greater than 150 g of the dispensed liquid in each administration; wherein the administration on the nasal-paranasal mucous membrane is carried out at a frequency ranging from 1 to 10 times a day; and wherein said water-based liquid comprises at least one selected from the group consisting of distilled water, bidistilled water, sterile tap water, physiological solution containing NaCl from 0.9% to 0.01% by weight with optional addition of glucose, Ringer solution, Ringer lactate solution, Hartmann solution, aqueous sulphur solution with a concentration ranging from 0.1 mg to 10 mg of H2S per liter, ionized alkaline water with a pH value ranging from 8 to 11, and deionised water.