Human lubrication gel

摘要

Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating gel being capable of adhering to the target tissue site and comprising one or more biodegradable formulations containing an effective amount of the therapeutic agent. In various embodiments, the human lubricating gel is sprayable and hardens after contacting the target tissue site.

主权项

1. A method for delivering a therapeutic agent into a target tissue site beneath the skin, the method comprising inserting a cannula at or near a target tissue site and injecting a human lubricating gel obtained from denatured collagen and being capable of adhering to the target tissue site, the human lubricating gel having a modulus of elasticity in a range of about 1×104 to about 6×105 dynes/cm2 after delivery to the target tissue site, the human lubricating gel comprising a plurality of microspheres, microcapsules, microfibers, particles, nanospheres, nanoparticles or mixtures thereof and containing an effective amount of the therapeutic agent, wherein the target tissue site comprises at least the tissue lining the sinus cavity, wherein the human lubricating gel further comprises human bone matrix gelatin in an amount of from about 1% to about 5% by weight based on a total weight of the gel.