Methods for targeting pulmonary diseases with agents that bind a target in pulmonary tissue

摘要

Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g., inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.

主权项

1. A method for treating acute respiratory distress syndrome (ARDS) in a patient comprising the steps of:
a) identifying a patient with ARDS; b) providing a formulation comprising a ligand that comprises a domain antibody comprising a CDR1 amino acid sequence, a CDR2 amino acid sequence and a CDR3 amino acid sequence of the domain antibody having the amino acid sequence shown in SEQ ID NO: 379; and c) administering the formulation locally to pulmonary tissue of the patient in an effective amount; whereby ARDS in the patient is treated.