| 发明名称 | Methods and compositions of improved modified siRNA | ||
| 摘要 | Chemically modified small interfering RNAs (siRNAs) that include both phosphorodithioate modifications (PS2-RNA) and 2′-O-methyl modifications (MePS2) provide improved RNA silencing. Specific chemically modified siRNA that show enhanced silencing of RNAs involved in resistance to chemotherapeutic agents are provided. | ||
| 申请公布号 | US9629867(B2) | 申请公布日期 | 2017.04.25 |
| 申请号 | US201514645351 | 申请日期 | 2015.03.11 |
| 申请人 | AM Biotechnologies, Inc. | 发明人 | Yang Xianbin |
| 分类号 | A61K48/00;C12N15/11;C07H21/02;C07H21/04;A61K31/713;A61K45/06;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | Blank Rome LLP | 代理人 | Blank Rome LLP |
| 主权项 | 1. A chemically modified siRNA directed to interference with a RISC Ago2 slicer associated with chemoresistance in ovarian cancer cell lines and tumors, wherein the chemical modifications to the siRNA comprise a combination of 2′-OMe and PS2 modifications on either or both sense and antisense strands of the siRNA that improve serum stability and gene silencing efficacy. | ||
| 地址 | Houston TX US | ||