发明名称 |
Use of an IL-31 monoclonal antibody for antagonizing signal transduction in spinal cord cells |
摘要 |
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated. |
申请公布号 |
US9631021(B2) |
申请公布日期 |
2017.04.25 |
申请号 |
US201615099639 |
申请日期 |
2016.04.15 |
申请人 |
ZYMOGENETICS INC. |
发明人 |
Yao Yue;Bilsborough Janine |
分类号 |
A61K39/395;C07K16/24;C07K14/54;C07K16/28;A61K38/17;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
Walsh Brian J. |
主权项 |
1. A method of antagonizing signal transduction in spinal cord cells of a mammal, comprising administering to the mammal a humanized monoclonal antibody derived from the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815, wherein the humanized monoclonal antibody comprises a human IgG4 heavy chain immunoglobulin constant domain, and wherein after administration the signal transduction in the mammal's spinal cord cells is reduced. |
地址 |
Seattle WA US |