Compounds that modulate autoimmunity and methods of using the same

摘要

The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.

主权项

1. A method of preventing, treating or ameliorating autoimmune diabetes by administering to a mammal in need of such treatment, a therapeutically effective amount of a compound selected from the group consisting of:
1,3,6,8-tetraazatricyclo[4.4.1.1(3,8)]dodecane, 1-ethyl-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-allyl-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-(15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]dec-1-yl)acetone, 1-(2,4,5-trichlorobenzyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-bromo-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 2-(15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]dec-1-yl)ethanol, 1-(4-chloro-2-butenyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-(2-chloro-2-propenyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-benzyl-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-(2,3-dibromo-2-propenyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, 1-(3-chloro-2-propenyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, and 1-(2-oxiranylmethyl)-15,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane, and pharmaceutically-acceptable salts thereof.