| 发明名称 | Microsphere compositions, preparation method and applications thereof | ||
| 摘要 | A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix A-B-A wherein A is selected from poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof. | ||
| 申请公布号 | US9629811(B2) | 申请公布日期 | 2017.04.25 |
| 申请号 | US201314389211 | 申请日期 | 2013.03.29 |
| 申请人 | Institut National de la Sante et de la Recherche Medicale (INSERM) | 发明人 | Morille Marie;Tran Van-Thanh;Garric Xavier;Coudane Jean;Venier-Julienne Marie-Claire;Montero-Menei Claudia |
| 分类号 | A61K9/50;A61K9/48;A61K38/16;A61K35/00;A61K9/16 | 主分类号 | A61K9/50 |
| 代理机构 | Whitham, Curtis & Cook, P.C. | 代理人 | Whitham, Curtis & Cook, P.C. |
| 主权项 | 1. A cell carrying microsphere composition, wherein the microsphere composition consists of: a microspheric core comprising a copolymer matrix A-B-A, wherein A is poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is a poloxamer or a poloxamine, wherein the microspheric core is coated with a cell adhesion coating, whole cells or cell fragments bound to the cell adhesion coating, and optionally, an active ingredient embedded within the microspheric core. | ||
| 地址 | Paris FR | ||